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Proceedings Paper

Brain tumor resection guided by fluorescence imaging and MRI image guidance
Author(s): Pablo Valdes; Brent T. Harris; Frederic Leblond; Kathryn M. Fontaine; Songbai Ji; Brian W. Pogue; Alex Hartov; David W. Roberts; Keith D. Paulsen
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Paper Abstract

Recent evidence suggests a correlation between extent of tumor resection and patient prognosis, making maximal tumor resection a clinical ideal for neurosurgeons. Our group is currently undertaking a clinical study using fluorescence-based detection of tumor coupled with a standard 3-D image guidance system to study the effectiveness of fluorescence-based detection in the neurosurgical operating room. For fluorescence-based detection, we used 5-aminolevulinic acid to induce accumulation of protoporphyrin IX in malignant tissues. In this paper, we chose one prototypical, highly fluorescent case of glioblastoma multiforme, a high-grade glioma, to highlight some of the key findings and methodology used in our study of fluorescence-based detection and resection of brain tumors.

Paper Details

Date Published: 13 March 2009
PDF: 8 pages
Proc. SPIE 7261, Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling, 726103 (13 March 2009); doi: 10.1117/12.813868

Published in SPIE Proceedings Vol. 7261:
Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling
Michael I. Miga; Kenneth H. Wong, Editor(s)

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