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Proceedings Paper

Implementation OSEM mesh-domain SPECT reconstruction with explicit prior information
Author(s): Andrzej Krol; Levon Vogelsang; Yao Lu; Yuesheng Xu; Xiaofei Hu; Lixin Shen; David Feiglin; Edward Lipson
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Paper Abstract

In order to improve reconstructed image quality, we investigated performance of OSEM mesh-domain SPECT reconstruction with explicit prior anatomical and physiological information that was used to perform accurate attenuation compensation. It was accomplished in the following steps: (i) Obtain anatomical and physiological atlas of desired region of interest; (ii) Generate mesh that encodes properties of the atlas; (iii) Perform initial pixel-based reconstruction on projection dataset; (iv) Register the expected emission atlas to the initial pixel-based reconstruction and apply resulting transformation to meshed atlas; (v) Perform reconstruction in mesh-domain using deformed mesh of the atlas. This approach was tested on synthetic SPECT noise-free and noisy data. Comparative quantitative analysis demonstrated that this method outperformed pixel-based OSEM with uniform AC and is a promising approach that might lead to improved SPECT reconstruction quality.

Paper Details

Date Published: 13 March 2009
PDF: 7 pages
Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 72585C (13 March 2009); doi: 10.1117/12.813815
Show Author Affiliations
Andrzej Krol, SUNY Upstate Medical Univ. (United States)
Syracuse Univ. (United States)
Levon Vogelsang, Syracuse Univ. (United States)
Yao Lu, Syracuse Univ. (United States)
Yuesheng Xu, Syracuse Univ. (United States)
Xiaofei Hu, Syracuse Univ. (United States)
Lixin Shen, Syracuse Univ. (United States)
David Feiglin, SUNY Upstate Medical Univ. (United States)
Syracuse Univ. (United States)
Edward Lipson, Syracuse Univ. (United States)
SUNY Upstate Medical Univ. (United States)


Published in SPIE Proceedings Vol. 7258:
Medical Imaging 2009: Physics of Medical Imaging
Ehsan Samei; Jiang Hsieh, Editor(s)

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