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Proceedings Paper

Visibility of microcalcifications in CCD-based cone beam CT: a preliminary study
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Paper Abstract

In this work, we investigated the visibility of microcalcifications in CCD-based cone beam CT (CBCT) breast imaging. A paraffin cylinder with a diameter of 135 mm and a thickness of 40 mm was used to simulate a 100% adipose breast. Calcium carbonate grains, ranging from 140-150 to 200-212 μm in size, were used to simulate the microcalcifications. Groups of 25 same size microcalcifications were arranged into 5 × 5 clusters. Each cluster was embedded at the center of a smaller (15 mm diameter) cylindrical paraffin phantom, which were inserted into a hole at the center of the breast phantom. The breast phantom with the simulated microcalcifications was scanned on a bench top experimental CCDbased cone beam CT system at various exposure levels with two CCD cameras: Hamamatsu's C4742-56-12ER and Dalsa 99-66-0000-00. 300 projection images were acquired over 360° and reconstructed with Feldkamp's backprojection algorithm using a ramp filter. The images were reviewed by 6 readers independently. The ratios of visible microcalcifications were recorded and averaged over all readers. These ratios were plotted as the function of measured image signal-to-noise ratio (SNR) for various scans. It was found that 94% visibility was achieved for 200-212 μm calcifications at an SNR of 48.2 while 50% visibility was achieved for 200-212, 180-200, 160-180, 150-160 and 140-150 μm calcifications at an SNR of 25.0, 35.3, 38.2, 42.2 and 64.4, respectively.

Paper Details

Date Published: 11 March 2009
PDF: 9 pages
Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 72580M (11 March 2009); doi: 10.1117/12.813806
Show Author Affiliations
Youtao Shen, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Lingyun Chen, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Shuaiping Ge, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Ying Yi, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Tao Han, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Yuncheng Zhong, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Chao-Jen Lai, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Xinming Liu, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Tianpeng Wang, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Chris C. Shaw, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 7258:
Medical Imaging 2009: Physics of Medical Imaging
Ehsan Samei; Jiang Hsieh, Editor(s)

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