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Proceedings Paper

Elastin peptides increase lung cancer cell growth in 3D models
Author(s): Jacek K. Pijanka; Ying Yang; Pierre O. Bagnaninchi; Laurent Debelle; Ganesh D. Sockalingum; Josep Sulé-Suso
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Paper Abstract

The lung is an organ heavily involved in cancer as both the origin of lung cancer and where metastases from tumours originating in other organs develop. Therefore, it is obvious that the interaction between cancer cells and lung tissue plays a role in cancer development, invasion, and/or growth. Out of all the components of the lung's extracellular matrix, elastin fragmentation products, the so-called elastin peptides, have been associated with tumour growth and invasion. Therefore, we studied using a 3D model whether elastin peptides could increase the proliferative activity of lung cancer cells. To this purpose, we grew lung cancer cells in collagen type I 3D models and used Optical Coherence Tomography to study lung cancer cells growth in the absence and presence of elastin peptides in real-time and at different time-points for each specimen. Our work shows that the addition of elastin peptides to lung cancer cells increased not only the size of the cancer cell clusters in 3D models but also the number of these clusters. This work demonstrates that, using OCT, the effects of extracellular matrix components on cancer cells can be characterised in 3D models. The biomedical applications of this methodology can be extended to other systems.

Paper Details

Date Published: 23 February 2009
PDF: 11 pages
Proc. SPIE 7179, Optics in Tissue Engineering and Regenerative Medicine III, 717907 (23 February 2009); doi: 10.1117/12.813743
Show Author Affiliations
Jacek K. Pijanka, Keele Univ. (United Kingdom)
Ying Yang, Keele Univ. (United Kingdom)
Pierre O. Bagnaninchi, Keele Univ. (United Kingdom)
Laurent Debelle, Lab. SiRMa, CNRS-MEDyC, Univ. de Reims (France)
Ganesh D. Sockalingum, CNRS-MEDyC, Univ. de Reims Champagne-Ardenne (France)
Josep Sulé-Suso, Keele Univ. (United Kingdom)
Univ. Hospital of North Staffordshire (United Kingdom)

Published in SPIE Proceedings Vol. 7179:
Optics in Tissue Engineering and Regenerative Medicine III
Sean J. Kirkpatrick; Ruikang Wang, Editor(s)

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