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Proceedings Paper

Comparison of ROC methods for partially paired data
Author(s): Brandon D. Gallas; Lorenzo L. Pesce
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Paper Abstract

In this work we investigate ROC methods that compare the difference in AUCs (area under the ROC curve) from two modalities given partially paired data. Such methods are needed to accommodate the real world situations, where every case cannot be imaged or interpreted using both modalities. We compare variance estimation of the bivariate binormal-model based method ROCKIT of Metz et al., as well as several different non-parametric methods, including the bootstrap and U-statistics. This comparison explores different ROC curves, study designs (pairing structure of the data), sample sizes, case mix, and modality effect sizes.

Paper Details

Date Published: 12 March 2009
PDF: 12 pages
Proc. SPIE 7263, Medical Imaging 2009: Image Perception, Observer Performance, and Technology Assessment, 72630V (12 March 2009); doi: 10.1117/12.813688
Show Author Affiliations
Brandon D. Gallas, FDA, Ctr. for Devices and Radiological Health (United States)
Lorenzo L. Pesce, The Univ. of Chicago (United States)

Published in SPIE Proceedings Vol. 7263:
Medical Imaging 2009: Image Perception, Observer Performance, and Technology Assessment
Berkman Sahiner; David J. Manning, Editor(s)

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