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Method for optic nerve intensity characterization in mice from Mn2+ enhanced MR imagesFormat | Member Price | Non-Member Price |
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Paper Abstract
Investigating whether manganese transport is impaired in the optic nerve of small animal model is a new approach for
evaluating optic neuritis. One needs to quantify signal intensity enhancement due to Mn2+ after intra-orbital injection,
along the optic nerve from MR images. Quantification is very challenging as the optic nerve (ON) is not straight, its
location does not correspond to standard slice orientation, the noise is substantial, and the signal is subject to
inhomogeneity from the coil sensitivity. In this paper, we propose a semi-automatic method whereby 1) the retina point
and the start of the chiasm in a mouse brain MR image are defined manually in a 3D visualization environment, 2) optic
nerve in reformatted slices perpendicular to the optic nerve segment is semi-manually selected, 3) an automatic
algorithm extracts the intensities along the optic nerve while correcting for intensity inhomogeneity, and 4) a model for
the Mn2+ diffusion with a exponential decay function is fitted to the intensity profile. Results for the study of
experimental autoimmune encephalomyelitis (EAE) are reported whereby statistically significant differences were found
between the EAE and the control group.
Paper Details
Date Published: 14 March 2009
PDF: 7 pages
Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 72584J (14 March 2009); doi: 10.1117/12.813351
Published in SPIE Proceedings Vol. 7258:
Medical Imaging 2009: Physics of Medical Imaging
Ehsan Samei; Jiang Hsieh, Editor(s)
PDF: 7 pages
Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 72584J (14 March 2009); doi: 10.1117/12.813351
Show Author Affiliations
D. Xiao, The Australian E-Health Research Ctr., ICTC, CSIRO (Australia)
J. Ribic, The Univ. of Melbourne (Australia)
Univ. of Oslo (Norway)
H. Butzkueven, The Univ. of Melbourne (Australia)
K. Fang, The Univ. of Melbourne (Australia)
J. Ribic, The Univ. of Melbourne (Australia)
Univ. of Oslo (Norway)
H. Butzkueven, The Univ. of Melbourne (Australia)
K. Fang, The Univ. of Melbourne (Australia)
T. J. Kilpatrick, The Univ. of Melbourne (Australia)
G. F. Egan, The Univ. of Melbourne (Australia)
O. Salvado, The Australian E-Health Research Ctr., ICTC, CSIRO (Australia)
G. F. Egan, The Univ. of Melbourne (Australia)
O. Salvado, The Australian E-Health Research Ctr., ICTC, CSIRO (Australia)
Published in SPIE Proceedings Vol. 7258:
Medical Imaging 2009: Physics of Medical Imaging
Ehsan Samei; Jiang Hsieh, Editor(s)
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