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Proceedings Paper

Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy
Author(s): Jessica Lupinacci; Neb Duric; Peter Littrup; Ding Wang; Cuiping Li; Steven Schmidt; Olsi Rama; Lisa Bey-Knight; Lukasz Myc
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Paper Abstract

As part of an ongoing assessment of the in-vivo performance of a operator independent breast imaging device, based on acoustic tomography, we report on new results obtained with patients undergoing neoadjuvant chemotherapy. Five patients were examined with the prototype on multiple occasions corresponding in time to their chemotherapy sessions. Images of reflection, sound speed and attenuation, representing the entire volume of the breast, were reconstructed from the exam data and analyzed for time-dependent changes during the treatment period. It was found that changes in acoustic properties of the tumors could be measured directly from the images. The measured properties include reflectivity, sound speed and attenuation, leading to measurable changes in the volume, shape and internal attributes of the tumors. These measurements were used to monitor the response of the tumors to the therapy with the long term goal of correlating results with pathological and clinical outcomes. Comparisons with tumor size changes based on traditional US and MRI indicates potential for accurate, quantifiable tracking of tumor volume. Furthermore, our tentative results also show declines in internal properties of the tumors, possibly relating to a reduction in tissue stiffness and/or density. Future work will include an expansion of the study to a larger cohort of patients for determining the statistical significance of our findings.

Paper Details

Date Published: 14 March 2009
PDF: 9 pages
Proc. SPIE 7265, Medical Imaging 2009: Ultrasonic Imaging and Signal Processing, 726517 (14 March 2009); doi: 10.1117/12.812975
Show Author Affiliations
Jessica Lupinacci, Karmanos Cancer Institute, Wayne State Univ. (United States)
Neb Duric, Karmanos Cancer Institute, Wayne State Univ. (United States)
Peter Littrup, Karmanos Cancer Institute, Wayne State Univ. (United States)
Ding Wang, Karmanos Cancer Institute, Wayne State Univ. (United States)
Cuiping Li, Karmanos Cancer Institute, Wayne State Univ. (United States)
Steven Schmidt, Karmanos Cancer Institute, Wayne State Univ. (United States)
Olsi Rama, Karmanos Cancer Institute, Wayne State Univ. (United States)
Lisa Bey-Knight, Karmanos Cancer Institute, Wayne State Univ. (United States)
Lukasz Myc, Karmanos Cancer Institute, Wayne State Univ. (United States)


Published in SPIE Proceedings Vol. 7265:
Medical Imaging 2009: Ultrasonic Imaging and Signal Processing
Stephen A. McAleavey; Jan D'hooge, Editor(s)

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