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Proceedings Paper

HyperSPECT: a new system for pre-clinical imaging in vivo
Author(s): Sandra Tibbelin; Peter Nillius; Björn Cederström; Mats Danielsson
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Paper Abstract

Imaging in general is becoming increasingly important in the medical science. At the cell level it is possible to label and trace almost individual molecules in vivo to study biochemical reactions using microscopy. In vivo imaging of living organisms is today mainly accomplished by PET, SPECT and fMRI. The problem is that the spatial resolution for realistic image acquisition times is of the order 1-3 mm, which is a serious limitation. We propose a new imaging modality, based on the same principles as SPECT but with drastically improved efficiency and spatial resolution. This is achieved by incorporating a large number of x-ray lenses between the detectors and the object. In current SPECT a pin-hole geometry is standard, involving an unfortunate trade-off between efficiency and spatial resolution, our solution would change this. The agent for radiolabelling is assumed to be 125I, with an emission peak at 27 keV, since it is widely used and easy to handle. The large area, photon counting detectors will consist of a columnar CsI scintillator coupled to a CMOS integrated circuit for electronic read-out. Our simulations of the entire system and of the detector indicate that a resolution of 50 μm for the system is possible.

Paper Details

Date Published: 13 March 2009
PDF: 8 pages
Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 72580X (13 March 2009); doi: 10.1117/12.812964
Show Author Affiliations
Sandra Tibbelin, The Royal Institute of Technology (Sweden)
Peter Nillius, The Royal Institute of Technology (Sweden)
Björn Cederström, The Royal Institute of Technology (Sweden)
Mats Danielsson, The Royal Institute of Technology (Sweden)


Published in SPIE Proceedings Vol. 7258:
Medical Imaging 2009: Physics of Medical Imaging
Ehsan Samei; Jiang Hsieh, Editor(s)

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