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Proceedings Paper

Mapping ventricular expansion and its clinical correlates in Alzheimer's disease and mild cognitive impairment using multi-atlas fluid image alignment
Author(s): Yi-Yu Chou; Natasha Lepore; Christina Avedissian; Sarah K. Madsen; Xue Hua; Clifford R. Jack Jr.; Michael W. Weiner; Arthur W. Toga; Paul M. Thompson
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Paper Abstract

We developed an automated analysis pipeline to analyze 3D changes in ventricular morphology; it provides a highly sensitive quantitative marker of Alzheimer's disease (AD) progression for MRI studies. In the ADNI image database, we created expert delineations of the ventricles, as parametric surface meshes, in 6 brain MRI scans. These 6 images and their embedded surfaces were fluidly registered to MRI scans of 80 AD patients, 80 individuals with mild cognitive impairment (MCI), and 80 healthy controls. Surface averaging within subjects greatly reduced segmentation error. Surface-based statistical maps revealed powerful correlations between surface morphology at baseline and (1) diagnosis, (2) cognitive performance (MMSE scores), (3) depression, and (4) predicted future decline, over a 1 year interval, in 3 standard clinical scores (MMSE, global and sum-of-boxes CDR). We used a false discovery rate method (FDR) method based on cumulative probability plots to find that 40 subjects were sufficient to discriminate AD from normal groups. 60 and 119 subjects, respectively, were required to correlate ventricular enlargement with MMSE and clinical depression. Surface-based FDR, along with multi-atlas fluid registration to reduce segmentation error, will allow researchers to (1) estimate sample sizes with adequate power to detect groups differences, and (2) compare the power of mapping methods head-to-head, optimizing cost-effectiveness for future clinical trials.

Paper Details

Date Published: 27 March 2009
PDF: 8 pages
Proc. SPIE 7259, Medical Imaging 2009: Image Processing, 725930 (27 March 2009); doi: 10.1117/12.812411
Show Author Affiliations
Yi-Yu Chou, Univ. of California, Los Angeles (United States)
Natasha Lepore, Univ. of California, Los Angeles (United States)
Christina Avedissian, Univ. of California, Los Angeles (United States)
Sarah K. Madsen, Univ. of California, Los Angeles (United States)
Xue Hua, Univ. of California, Los Angeles (United States)
Clifford R. Jack Jr., Mayo Clinic College of Medicine (United States)
Michael W. Weiner, Univ. of California, San Francisco (United States)
Arthur W. Toga, Univ. of California, Los Angeles (United States)
Paul M. Thompson, Univ. of California, Los Angeles (United States)

Published in SPIE Proceedings Vol. 7259:
Medical Imaging 2009: Image Processing
Josien P. W. Pluim; Benoit M. Dawant, Editor(s)

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