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Proceedings Paper

Choline molecular imaging with small-animal PET for monitoring tumor cellular response to photodynamic therapy of cancer
Author(s): Baowei Fei; Hesheng Wang; Chunying Wu; Joseph Meyers; Liang-Yan Xue; Gregory MacLennan; Mark Schluchter
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Paper Abstract

We are developing and evaluating choline molecular imaging with positron emission tomography (PET) for monitoring tumor response to photodynamic therapy (PDT) in animal models. Human prostate cancer (PC-3) was studied in athymic nude mice. A second-generation photosensitizer Pc 4 was used for PDT in tumor-bearing mice. MicroPET images with 11C-choline were acquired before PDT and 48 h after PDT. Time-activity curves of 11C-choline uptake were analyzed before and after PDT. For treated tumors, normalized choline uptake decreased significantly 48 h after PDT, compared to the same tumors pre-PDT (p ⪅ 0.001). However, for the control tumors, normalized choline uptake increased significantly (p ⪅ 0.001). PET imaging with 11C-choline is sensitive to detect early tumor response to PDT in the animal model of human prostate cancer.

Paper Details

Date Published: 28 February 2009
PDF: 8 pages
Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 726211 (28 February 2009); doi: 10.1117/12.812129
Show Author Affiliations
Baowei Fei, Emory Univ. (United States)
Case Western Reserve Univ. (United States)
Hesheng Wang, Case Western Reserve Univ. (United States)
Emory Univ. (United States)
Chunying Wu, Case Western Reserve Univ. (United States)
Joseph Meyers, Case Western Reserve Univ. (United States)
Liang-Yan Xue, Case Western Reserve Univ. (United States)
Gregory MacLennan, Case Western Reserve Univ. (United States)
Mark Schluchter, Case Western Reserve Univ. (United States)


Published in SPIE Proceedings Vol. 7262:
Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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