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Proceedings Paper

Preliminary study of cytotoxic effects of photodynamic therapy and immunotherapy on human pancreatic cancer cells
Author(s): Luowei Wang; Bolin Liu; Yang K. Chen; Zhaoshen Li; Fred W. Hetzel; Zheng Huang
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Paper Abstract

Pancreatic cancer is the fourth most common cause of cancer death in the western world. The disease is very resistant to radiotherapy and chemotherapy. One reason for that is the resistance of pancreatic cancer cells to apoptosis. Among the current investigational approaches, targeting human epidermal growth factor receptor (HER-1/EGFR) and interstitial photodynamic therapy (PDT) show promises. When used alone or together, these new approaches might provide an alternative modality to treat pancreatic cancer. This study examined and compared cytotoxic effects of antibody C225 (an anti-HER-1/EGFR monoclonal antibody) and Photofrin-mediated PDT on two human pancreatic cancer cell lines (BxPc-3, HPAF-II). Preliminary in vitro data indicated that these treatments could block various proliferation pathways of pancreatic cancer cells through different mechanisms. For instance, PDT could induce early apoptosis. C225 could induce G1 arrest. These findings might help to design new strategies such as the combination of PDT and immunotherapy for the treatment of pancreatic cancer.

Paper Details

Date Published: 24 February 2009
PDF: 8 pages
Proc. SPIE 7178, Biophotonics and Immune Responses IV, 71780C (24 February 2009); doi: 10.1117/12.811904
Show Author Affiliations
Luowei Wang, Changhai Hospital, The 2nd Military Medical Univ. (China)
Univ. of Colorado at Denver (United States)
Bolin Liu, Univ. of Colorado at Denver (United States)
Yang K. Chen, Univ. of Colorado at Denver (United States)
Zhaoshen Li, Changhai Hospital, The 2nd Military Medical Univ. (China)
Fred W. Hetzel, Univ. of Colorado at Denver (United States)
Zheng Huang, Univ. of Colorado at Denver (United States)

Published in SPIE Proceedings Vol. 7178:
Biophotonics and Immune Responses IV
Wei R. Chen, Editor(s)

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