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Proceedings Paper

Assessing the feasibility for a poroelastic reconstruction algorithm in MR elastography
Author(s): Phillip R. Perrinez; Francis E. Kennedy; John B. Weaver; Keith D. Paulsen
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Paper Abstract

Implementing constitutive relations that accurately describe the mechanical behavior of biological tissues in vivo is integral to the success of any model-based elastographic reconstruction technique, and the diagnostic value of the recovered images. Recently, poroelastic theory has been used to model tissue and other materials comprised of two distinct phases. Current linearly elastic techniques are not capable of fully describing the complex mechanical behavior of fluid-saturated tissues because they consider only a single solid phase, neglecting the influence of extracellular fluid. In an attempt to model the deformation of biological tissues more effectively in vivo by employing constitutive relations which are more representative of tissue structure and physiology, a three-dimensional (3D) finite element reconstruction algorithm has been developed based on the equations of dynamic poroelasticity. The algorithm operates on a single domain of O(103) nodes. The performance of the algorithm was tested using simulated data. The results suggest that the technique is capable of recovering accurate distributions of the underlying mechanical properties of the solid matrix as well as the time-harmonic pressure field resulting from tissue vibration.

Paper Details

Date Published: 27 February 2009
PDF: 7 pages
Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 72621E (27 February 2009); doi: 10.1117/12.811714
Show Author Affiliations
Phillip R. Perrinez, Dartmouth College (United States)
Francis E. Kennedy, Dartmouth College (United States)
John B. Weaver, Dartmouth College (United States)
Dartmouth-Hitchcock Medical Ctr. (United States)
Keith D. Paulsen, Dartmouth College (United States)
Dartmouth-Hitchcock Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 7262:
Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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