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Proceedings Paper

Implementation of an effective KL domain penalized weighted least-squares sinogram restoration for low-dose CT colonography
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Paper Abstract

Currently available spiral/helical computed tomography (HCT) technologies have demonstrated the potential for CTbased virtual colonoscopy or CT-colonography (CTC). However, a major limitation for this clinical application is associated with the risk of high radiation exposure, especially for its use for screening purpose at a large population. In this work, we presented an improved Karhunen-Loeve (KL) domain penalized weighted least-squares (PWLS) strategy which considers the data correlation among the nearby angular views and nearby axial slices simultaneously so that a fully three-dimensional (3D) restoration problem can be reduced to a 1D operation and therefore an analytical calculation is feasible for highest computing efficiency. The KL-PWLS strategy was implemented and tested on computer simulated sinograms which mimic low-dose CT scans at different noise levels characterized by 50, 40, 30, 20 and 10 mAs respectively. The reconstructed images by the presented strategy demonstrated the potential of ultra low-dose CT at as low as 10 mAs for VC application. Further evaluation by receiver operating characteristic study is needed and is under progress.

Paper Details

Date Published: 13 March 2009
PDF: 7 pages
Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 725856 (13 March 2009); doi: 10.1117/12.811670
Show Author Affiliations
Yi Fan, Stony Brook Univ. (United States)
Jing Wang, Stony Brook Univ. (United States)
Hongbing Lu, Fourth Military Medical Univ. (China)
Zhengrong Liang, Stony Brook Univ. (United States)


Published in SPIE Proceedings Vol. 7258:
Medical Imaging 2009: Physics of Medical Imaging
Ehsan Samei; Jiang Hsieh, Editor(s)

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