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Proceedings Paper

DPN writing on non-flat gold surfaces and detection by SERS
Author(s): Robert J. Stokes; Jennifer A. Dougan; Eleanore Irvine; Jenifer Ohayon; Sergey Rozhok; Tom Levesque; Bruce Dudzik; Mike Nelson; Duncan Graham
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Paper Abstract

There is a need for fast, reliable and sensitive biosensor arrays. We have used nanostructured plasmonic gold surfaces for the detection of biological species by surface enhanced resonance Raman scattering (SERRS). Careful, directed placement by Dip-Pen Nanolithography (DPN) of the biological species or capture chemistry, within the array facilitates efficient read out via fast Raman line mapping. In addition, we can apply parallel deposition methods to enhance the throughput of these combined techniques. SERRS is an extremely sensitive spectroscopic technique that offers several advantages over conventional fluorescence detection. For example, the high sensitivity of the method allows detection of DNA capture from single plasmonic array "pixels" ~1 μm2 in area. Additionally, the information rich nature of the SERRS spectrum allows multiple levels of detection to be embedded into each pixel, further increasing the information depth of the array. By moving from micro- to nano-scale features, sensor chips can contain up to 105 times more information, dramatically increasing the capacity for disease screening.

Paper Details

Date Published: 18 February 2009
PDF: 7 pages
Proc. SPIE 7207, Microfluidics, BioMEMS, and Medical Microsystems VII, 720703 (18 February 2009); doi: 10.1117/12.811523
Show Author Affiliations
Robert J. Stokes, Univ. of Strathclyde (United Kingdom)
Jennifer A. Dougan, Univ. of Strathclyde (United Kingdom)
Eleanore Irvine, Univ. of Strathclyde (United Kingdom)
Jenifer Ohayon, NanoInk, Inc. (United States)
Sergey Rozhok, NanoInk, Inc. (United States)
Tom Levesque, NanoInk, Inc. (United States)
Bruce Dudzik, NanoInk, Inc. (United States)
Mike Nelson, NanoInk, Inc. (United States)
Duncan Graham, Univ. of Strathclyde (United Kingdom)

Published in SPIE Proceedings Vol. 7207:
Microfluidics, BioMEMS, and Medical Microsystems VII
Wanjun Wang, Editor(s)

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