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Proceedings Paper

Design and realization of label-free optical immunosensor based on porous silicon microcavities
Author(s): Xiao-yi Lü; Tao Xue; Zhen-hong Jia; Hua-wei Shao; Shi-bin Hou; Fu-chun Zhang
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Paper Abstract

We report the experimental demonstration of a novel label-free optical immunosensor based on porous silicon microcavity for the detection of Hydroxysafflor yellow A (HYSA). HYSA antibodies were immobilized into the porous silicon using standard amino-silane and glutaraldehyde chemistry. We monitor the shift of the resonance dip in the reflectance spectrum when HYSA-BSA is attached to the porous silicon microcavity. The label-free immunosensor is simple and exhibit excellent sensitivity for HYSA antibodies with a sensitivity of 0.91nm/ng.

Paper Details

Date Published: 2 February 2009
PDF: 8 pages
Proc. SPIE 7157, 2008 International Conference on Optical Instruments and Technology: Advanced Sensor Technologies and Applications, 71571E (2 February 2009); doi: 10.1117/12.811386
Show Author Affiliations
Xiao-yi Lü, Xi'an Jiaotong Univ. (China)
Xinjiang Univ. (China)
Tao Xue, Xinjiang Univ. (China)
Zhen-hong Jia, Xinjiang Univ. (China)
Hua-wei Shao, Xinjiang Univ. (China)
Shi-bin Hou, Xinjiang Univ. (China)
Fu-chun Zhang, Xinjiang Univ. (China)


Published in SPIE Proceedings Vol. 7157:
2008 International Conference on Optical Instruments and Technology: Advanced Sensor Technologies and Applications
Anbo Wang; YanBiao Liao; AiGuo Song; Yukihiro Ishii; Xudong Fan, Editor(s)

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