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Proceedings Paper

Three-dimensional localization of in vivo bioluminescent source based on multispectral imaging
Author(s): Jinchao Feng; Kebin Jia; Jie Tian; Guorui Yan; Shouping Zhu
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Paper Abstract

Bioluminescence tomography (BLT) is a novel in vivo technique in small animal studies, which can reveal the molecular and cellular information at the whole-body small animal level. At present, there is an increasing interest in multispectral bioluminescence tomography, since multispectral data acquisition could improve the BLT performance significantly. In view to the ill-posedness of BLT problem, we develop an optimal permissible source region strategy to constrain the possible solution of the source by utilizing spectrum character of bioluminescent source. Then a linear system to link the measured data with the unknown light source variables is established by utilizing the optimal permissible region strategy based on adaptive finite element analysis. Furthermore, singular value decomposition analysis is used for data dimensionality reduction and improving computational efficiency in multispectral case. The reconstructed speed and stability benefit from adaptive finite element, the permissible region strategy and singular value decomposition. In the numerical simulation, the heterogeneous phantom experiment has been used to evaluate the performance of the proposed algorithm with the Monte Carlo based synthetic data. The reconstruction results demonstrate the merits and potential of our methodology for localizing bioluminescent source.

Paper Details

Date Published: 27 February 2009
PDF: 8 pages
Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 72622C (27 February 2009); doi: 10.1117/12.811329
Show Author Affiliations
Jinchao Feng, Beijing Univ. of Technology (China)
Kebin Jia, Beijing Univ. of Technology (China)
Jie Tian, Institute of Automation (China)
Xidian Univ. (China)
Guorui Yan, Institute of Automation (China)
Shouping Zhu, Institute of Automation (China)


Published in SPIE Proceedings Vol. 7262:
Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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