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Proceedings Paper

MRI-guided focused ultrasound (MRgFUS) system for thermal ablation of prostate cancer: pre-clinical evaluation in canines
Author(s): Nathan McDannold; Hadas Ziso; Benny Assif; Arik Hananel; Natalia Vykhodtseva; Peri Gretton; Magdalini Pilatou; Steven Haker; Clare Tempany
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Paper Abstract

A transrectal MRgFUS system was tested in a canine prostate model. Focal volumes in each half of the prostate were targeted, with high energy in one half of the gland for ablation and in the other with lower-energy sonications to test our ability to localize the focal spot before causing thermal tissue damage. All sonications (n=155) were readily observed with proton resonance frequency (PRF) MR temperature imaging, contrast enhanced MRI and histology. The prostate gland moved during the experiments, demonstrating the need for motion tracking. The resultant focal temperature changes during the experiments were 24.2 ± 8.2°C.

Paper Details

Date Published: 23 February 2009
PDF: 6 pages
Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 71810H (23 February 2009); doi: 10.1117/12.811178
Show Author Affiliations
Nathan McDannold, Harvard Medical School (United States)
Brigham and Women's Hospital (United States)
Hadas Ziso, InSightec Ltd. (Israel)
Benny Assif, InSightec Ltd. (Israel)
Arik Hananel, InSightec Ltd. (Israel)
Natalia Vykhodtseva, Harvard Medical School (United States)
Brigham and Women's Hospital (United States)
Peri Gretton, InSightec Ltd. (Israel)
Magdalini Pilatou, Harvard Medical School (United States)
Brigham and Women's Hospital (United States)
Steven Haker, Harvard Medical School (United States)
Brigham and Women's Hospital (United States)
Clare Tempany, Harvard Medical School (United States)
Brigham and Women's Hospital (United States)


Published in SPIE Proceedings Vol. 7181:
Energy-based Treatment of Tissue and Assessment V
Thomas P. Ryan, Editor(s)

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