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Proceedings Paper

Application of an image-guided navigation system in breast cancer localization
Author(s): Tanja Alderliesten; Claudette Loo; Angelique T. E. F. Schlief; Anita Paape; Michiel van der Meer; Kenneth G. A. Gilhuijs
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Paper Abstract

Image-guided navigation on the basis of pre-therapy images in a deformable organ, such as the breast, requires a survey of the factors that cause uncertainties. A deformable breast-tissue-mimicking phantom with simulated tumors was employed to investigate the accuracy of lesion localization with a needle instrument coupled to an optical measurement system. The RMS deviation was 1.1 mm with errors ≤ 2.0 mm in 96% of the procedures. Ultrasonography data acquired during needle localization of breast tumors were analyzed in 20 patients (23 tumors; 12 benign, 11 malignant) to investigate the deformation due to presence of instruments. The overall RMS tumor shift was 2.3 mm after release of pressure on the needle. To establish an optimal strategy to correct for breast motion due to breathing experiments with a volunteer were performed. Tracking a single centre marker was found to be most effective to improve registration accuracy. Average deviations of 8.2 mm were reduced to 1.1 mm. The combined impact of these different uncertainties resulted in distributions defined by: μ = 2.5 mm, σ = 1.4 mm (benign and malignant), μ = 3.1 mm, σ = 1.8 mm (benign), μ = 1.7 mm, σ = 0.9 mm (malignant).

Paper Details

Date Published: 13 March 2009
PDF: 8 pages
Proc. SPIE 7261, Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling, 726111 (13 March 2009); doi: 10.1117/12.811121
Show Author Affiliations
Tanja Alderliesten, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital (Netherlands)
Claudette Loo, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital (Netherlands)
Angelique T. E. F. Schlief, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital (Netherlands)
Anita Paape, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital (Netherlands)
Michiel van der Meer, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital (Netherlands)
Kenneth G. A. Gilhuijs, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital (Netherlands)


Published in SPIE Proceedings Vol. 7261:
Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling
Michael I. Miga; Kenneth H. Wong, Editor(s)

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