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Proceedings Paper

3D variational brain tumor segmentation on a clustered feature set
Author(s): Karteek Popuri; Dana Cobzas; Martin Jagersand; Sirish L. Shah; Albert Murtha
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Paper Abstract

Tumor segmentation from MRI data is a particularly challenging and time consuming task. Tumors have a large diversity in shape and appearance with intensities overlapping the normal brain tissues. In addition, an expanding tumor can also deflect and deform nearby tissue. Our work addresses these last two difficult problems. We use the available MRI modalities (T1, T1c, T2) and their texture characteristics to construct a multi-dimensional feature set. Further, we extract clusters which provide a compact representation of the essential information in these features. The main idea in this paper is to incorporate these clustered features into the 3D variational segmentation framework. In contrast to the previous variational approaches, we propose a segmentation method that evolves the contour in a supervised fashion. The segmentation boundary is driven by the learned inside and outside region voxel probabilities in the cluster space. We incorporate prior knowledge about the normal brain tissue appearance, during the estimation of these region statistics. In particular, we use a Dirichlet prior that discourages the clusters in the ventricles to be in the tumor and hence better disambiguate the tumor from brain tissue. We show the performance of our method on real MRI scans. The experimental dataset includes MRI scans, from patients with difficult instances, with tumors that are inhomogeneous in appearance, small in size and in proximity to the major structures in the brain. Our method shows good results on these test cases.

Paper Details

Date Published: 27 March 2009
PDF: 10 pages
Proc. SPIE 7259, Medical Imaging 2009: Image Processing, 72591N (27 March 2009); doi: 10.1117/12.811029
Show Author Affiliations
Karteek Popuri, Univ. of Alberta (Canada)
Dana Cobzas, Univ. of Alberta (Canada)
Martin Jagersand, Univ. of Alberta (Canada)
Sirish L. Shah, Univ. of Alberta (Canada)
Albert Murtha, Univ. of Alberta (Canada)


Published in SPIE Proceedings Vol. 7259:
Medical Imaging 2009: Image Processing
Josien P. W. Pluim; Benoit M. Dawant, Editor(s)

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