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Proceedings Paper

Iterative finite-element-based inversion for quantified detection of molecular targets using optoacoustic tomography
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Paper Abstract

We describe an improved optoacoustic tomography method, that utilizes a diffusion-based photon propagation model in order to obtain quantified reconstruction of targets embedded deep in heterogeneous scattering and absorbing tissue. For the correction we utilize an iterative finite-element solution of the light diffusion equation to build a photon propagation model. We demonstrate image improvements achieved by this method by using tissue-mimicking phantom measurements. The particular strength of the method is its ability to achieve quantified reconstructions in non-uniform illumination configurations resembling whole-body small animal imaging scenarios.

Paper Details

Date Published: 13 March 2009
PDF: 8 pages
Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 725812 (13 March 2009); doi: 10.1117/12.811014
Show Author Affiliations
Thomas Jetzfellner, Institute for Biological and Medical Imaging (Germany)
Helmholtz Ctr. Munich (Germany)
Daniel Razansky, Institute for Biological and Medical Imaging (Germany)
Helmholtz Ctr. Munich (Germany)
Amir Rosenthal, Institute for Biological and Medical Imaging (Germany)
Helmholtz Ctr. Munich (Germany)
Ralf Schulz, Institute for Biological and Medical Imaging (Germany)
Helmholtz Ctr. Munich (Germany)
K.-H. Englmeier, Institute for Biological and Medical Imaging (Germany)
Helmholtz Ctr. Munich (Germany)
Vasilis Ntziachristos, Institute for Biological and Medical Imaging (Germany)
Helmholtz Ctr. Munich (Germany)


Published in SPIE Proceedings Vol. 7258:
Medical Imaging 2009: Physics of Medical Imaging
Ehsan Samei; Jiang Hsieh, Editor(s)

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