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Proceedings Paper

In vivo confocal Raman spectroscopy for skin disease diagnosis and characterization: preliminary results from mouse tumor models
Author(s): Hequn Wang; Naiyan Huang; Jianhua Zhao; Harvey Lui; Mladen Korbelik; Haishan Zeng
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Paper Abstract

As applied to microscopy, the confocal technique is a powerful method that can non-invasively provide depth-resolved information on tissue because of its optical sectioning capability. Raman spectroscopy is a non-invasive optical technique that is very sensitive to the structure and conformation of biochemical constitutes. Combining these two distinct techniques can non-invasively provide depth-resolved biochemical information of the skin in vivo. In this paper, we present a novel confocal Raman spectrometer and preliminary results on in vivo Raman spectral measurements of mouse tumor model. A total of 255 Raman spectra were taken from 15 mice in vivo. We found that Raman spectra of different sub-layers in mouse skin differ significantly. Obvious spectral changes for the dermis were also observed between normal skin and skin immediately overlying subcutaneous tumor.

Paper Details

Date Published: 19 February 2009
PDF: 9 pages
Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 716108 (19 February 2009); doi: 10.1117/12.810953
Show Author Affiliations
Hequn Wang, British Columbia Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada) and Vancouver Coastal Health Research Institute (Canada)
Naiyan Huang, British Columbia Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada) and Vancouver Coastal Health Research Institute (Canada)
Jianhua Zhao, British Columbia Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada) and Vancouver Coastal Health Research Institute (Canada)
Harvey Lui, British Columbia Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada) and Vancouver Coastal Health Research Institute (Canada)
Mladen Korbelik, British Columbia Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada) and Vancouver Coastal Health Research Institute (Canada)
Haishan Zeng, British Columbia Cancer Research Ctr. (Canada)
Univ. of British Columbia (Canada) and Vancouver Coastal Health Research Institute (Canada)


Published in SPIE Proceedings Vol. 7161:
Photonic Therapeutics and Diagnostics V
Henry Hirschberg; Brian Jet-Fei Wong; Kenton W. Gregory; Reza S. Malek; Nikiforos Kollias; Bernard Choi; Guillermo J. Tearney; Justus F. R. Ilgner; Steen J. Madsen; Laura Marcu; Haishan Zeng, Editor(s)

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