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Proceedings Paper

Rapid prototyping of microfluidic chips for use in droplet formation and in-vitro compartmentalisation
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Paper Abstract

The combined use of film transparency masks and dry film resist has allowed a rapid prototyping of designs and structures in chips for droplet generation. Patterning of the film resist has produced channels with smooth vertical sidewalls. The minimum feature dimension, δ, was reduced by increasing the resolution and spacing of the pattern geometries in the film mask. For a single layer of resist (~35 μm thick), a minimum feature width of ~60 μm was obtained using 2040 dpi transparency masks, 40 µm for 5800 dpi transparency masks and 25 μm using a Cr mask of equal size/ spacing of features. A doubling of the spacing between features in a 2400 dpi masks resulted in an attainable feature size of ~40 μm. The minimum feature dimension increased exponentially with thickness of 5038 resist. Microfluidic chips which were fabricated in PMMA by this method have demonstrated controlled characteristics in the generation of oil droplets in water.

Paper Details

Date Published: 30 December 2008
PDF: 8 pages
Proc. SPIE 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems, 72700K (30 December 2008); doi: 10.1117/12.810863
Show Author Affiliations
Patrick W. Leech, Commonwealth Scientific and Industrial Research Organisation (Australia)
Nan Wu, Commonwealth Scientific and Industrial Research Organisation (Australia)
Yonggang Zhu, Commonwealth Scientific and Industrial Research Organisation (Australia)


Published in SPIE Proceedings Vol. 7270:
Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems
Dan V. Nicolau; Guy Metcalfe, Editor(s)

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