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Proceedings Paper

Paramagnetic microchip for high-gradient separation of blood cell
Author(s): Ciprian Iliescu; Guolin Xu; Elena Barbarini; Marioara Avram; Florina S. Iliescu
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Paper Abstract

This paper presents a magnetophoretic separation method on a chip of white blood cells from blood under continuous flow. The separation of red blood cells from the whole blood is performed using a high gradient magnetic separation method under continuous flow to trap the particles inside the device. The device is fabricated by microfabrication technology and enables to capture the red blood cells without the use of labelling tecniques such as magnetic beads. The method consists of flowing diluted whole blood through a microfluidic channel where a ferromagnetic layer, subjected to a permanent magnetic field, is located. The majority of red blood cells are trapped at the bottom of the device while the rest of the blood is collected at the outlet. Experimental results show that an average of 95% of red blood cells are trapped in the device.

Paper Details

Date Published: 30 December 2008
PDF: 8 pages
Proc. SPIE 7269, Micro- and Nanotechnology: Materials, Processes, Packaging, and Systems IV, 726907 (30 December 2008); doi: 10.1117/12.810713
Show Author Affiliations
Ciprian Iliescu, Institute of Bioengineering and Nanotechnology (Singapore)
Guolin Xu, Institute of Bioengineering and Nanotechnology (Singapore)
Elena Barbarini, Politecnico di Torino (Italy)
Marioara Avram, National Institute for Research and Development in Microtechnologies (Romania)
Florina S. Iliescu, Republic Polytechnic (Singapore)


Published in SPIE Proceedings Vol. 7269:
Micro- and Nanotechnology: Materials, Processes, Packaging, and Systems IV
Jung-Chih Chiao; Alex J. Hariz; David V. Thiel; Changyi Yang, Editor(s)

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