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Proceedings Paper

HYPR-spectral photoacoustic CT for preclinical imaging
Author(s): Robert Kruger; Daniel Reinecke; Gabe Kruger; Michael Thornton; Paul Picot; Timothy Morgan; Keith Stantz; Charles Mistretta
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Paper Abstract

We have designed and built a prototype PCT (photoacoustic CT) scanner suitable for small animal imaging that acquires a sparse set of 128 photoacoustic, radial "projections" uniformly distributed over the surface of a hemisphere in response to optical absorption from a tunable, pulsed NIR (near-infrared) laser. Acquisition of a denser set of projections is achieved by rotating the hemispherical array about its vertical axis and acquiring additional, interleaved projections. Each detector in the array is a 3-mm diameter, piezo-composite with a center frequency of 5 MHz and 70% bandwidth. Spatial resolution is < 300 μm and nearly isotropic, owing to the array geometry. Preliminary results acquired at half of the allowable laser power and with no system optimizations show a low contrast sensitivity sufficient to detect a 350 nM concentration of a NIR-absorbing organic dye embedded in 12.5 mm of soft tissue. This scanner design will allow our group to take advantage of HYPR (HighlY constrained backPRojection) reconstruction techniques, which can significantly improve temporal (or spectral) resolution, without sacrificing signal-to-noise or spatial resolution. We will report how these accelerated reconstruction techniques can be implemented with this PCT scanner design. Using this approach, we may be able to achieve 100-ms temporal resolution for dynamic studies throughout a 20-mm-diameter imaging volume.

Paper Details

Date Published: 24 February 2009
PDF: 10 pages
Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71770F (24 February 2009); doi: 10.1117/12.810175
Show Author Affiliations
Robert Kruger, OptoSonics, Inc. (United States)
Daniel Reinecke, OptoSonics, Inc. (United States)
Gabe Kruger, OptoSonics, Inc. (United States)
Michael Thornton, Endra, Inc. (United States)
Paul Picot, Endra, Inc. (United States)
Timothy Morgan, Endra, Inc. (United States)
Keith Stantz, Purdue Univ. (United States)
Charles Mistretta, Univ. of Wisconsin-Madison (United States)

Published in SPIE Proceedings Vol. 7177:
Photons Plus Ultrasound: Imaging and Sensing 2009
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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