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Proceedings Paper

Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging
Author(s): Philip P. Cheney; Gregg B. Fields; Samuel Achilefu; W. Barry Edwards
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Paper Abstract

The prevalence of the gelatinases, MMP-2 and MMP-9, in many human tumors, including breast, colorectal, prostate and gastric cancer, make them an attractive target for molecular imaging. A self assembling homotrimeric triple helical peptide (THP), incorporating sequences from type V collagen with high specificity to MMP-2 and MMP-9, was previously developed. To investigate the viability of a THP for gelatinase imaging, we conjugated 5FAM to ..-amino groups of lysine flanking the hydrolysis site and subjected this substrate (THP-5FAM) to vitro analysis. The synthesis and in vitro results was presented.

Paper Details

Date Published: 20 February 2009
PDF: 8 pages
Proc. SPIE 7190, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications, 719011 (20 February 2009); doi: 10.1117/12.810096
Show Author Affiliations
Philip P. Cheney, Washington Univ. in St. Louis School of Medicine (United States)
Gregg B. Fields, Univ. of Texas at San Antonio Health Science Ctr. (United States)
Samuel Achilefu, Washington Univ. in St. Louis School of Medicine (United States)
W. Barry Edwards, Washington Univ. in St. Louis School of Medicine (United States)


Published in SPIE Proceedings Vol. 7190:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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