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Proceedings Paper

Determination of optical property changes by laser treatments using inverse adding-doubling method
Author(s): Norihiro Honda; Katsunori Ishii; Akinori Kimura; Makoto Sakai; Kunio Awazu
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Paper Abstract

It is widely recognized for the realization of the pre-estimated treatment effects that the knowledge about the optical properties of the target tissues used to understanding the prediction of propagation and distribution of light within tissues would suffer from the technical problem such as the kinetic changes of the optical properties in laser irradiation. In this study, the optical properties of normal and laser coagulated chicken breast tissues and porcine intervertebral disks, normal and laser ablation have been determined in vitro in the spectral range between 350 and 1000 nm. In addition, the optical properties of the normal and photodynamic therapy (PDT) treated tumor, Lewis lung carcinoma, tissues have been determined. Diffuse reflectance and total transmittance of the samples are measured using an integrating-sphere technique. From these experimental data, the absorption coefficients and the reduced scattering coefficients of the samples are determined employing an inverse adding-doubling method. Laser coagulations and ablations have clearly increased the reduced scattering coefficient and slightly reduced the absorption coefficient. PDT treatment has increased absorption and reduced scattering coefficient. It is our expectation that these data will provide fundamental understandings on laser irradiation interactions behavior with tissues. The changes of the optical properties should be accounted for while planning the therapeutic procedure for the realization of safe laser treatments.

Paper Details

Date Published: 12 February 2009
PDF: 8 pages
Proc. SPIE 7175, Optical Interactions with Tissue and Cells XX, 71750Q (12 February 2009); doi: 10.1117/12.810029
Show Author Affiliations
Norihiro Honda, Osaka Univ. (Japan)
Katsunori Ishii, Osaka Univ. (Japan)
Akinori Kimura, Osaka Univ. (Japan)
Makoto Sakai, Osaka Univ. (Japan)
Kunio Awazu, Osaka Univ. (Japan)
Japan Science and Technology Agency (Japan)

Published in SPIE Proceedings Vol. 7175:
Optical Interactions with Tissue and Cells XX
Steven L. Jacques; E. Duco Jansen; William P. Roach, Editor(s)

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