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Proceedings Paper

Third and second harmonic generation imaging of human articular cartilage
Author(s): Ming-Rung Tsai; Chih-Hwa Chen; Chi-Kuang Sun
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Paper Abstract

Cartilage matrix is damaged in diseased states such as osteoarthritis, while adult articular cartilage does not have the capacity to repair structural damage. A least invasive mean to diagnose these diseased states of human articular cartilage with a high spatial resolution is thus highly desired. In this paper, we present our harmonic generation microscopic studies on the human articular cartilage samples. Without any staining, third and second harmonic generation can provide strong contrast in chondrocytes and collagen matrix, respectively. Our study indicates the high capability of harmonic generation microscopy for future articular cartilage disease diagnosis.

Paper Details

Date Published: 13 February 2009
PDF: 10 pages
Proc. SPIE 7183, Multiphoton Microscopy in the Biomedical Sciences IX, 71831V (13 February 2009); doi: 10.1117/12.809968
Show Author Affiliations
Ming-Rung Tsai, National Taiwan Univ. (Taiwan)
Chih-Hwa Chen, Chang Gung Memorial Hospital at Keelung (Taiwan)
Chi-Kuang Sun, National Taiwan Univ. (Taiwan)
Research Ctr. for Applied Sciences (Taiwan)

Published in SPIE Proceedings Vol. 7183:
Multiphoton Microscopy in the Biomedical Sciences IX
Ammasi Periasamy; Peter T. C. So, Editor(s)

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