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Proceedings Paper

Laser speckle imaging of rat retinal blood flow with hybrid temporal and spatial analysis method
Author(s): Haiying Cheng; Yumei Yan; Timothy Q. Duong
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Paper Abstract

Noninvasive monitoring of blood flow in retinal circulation will reveal the progression and treatment of ocular disorders, such as diabetic retinopathy, age-related macular degeneration and glaucoma. A non-invasive and direct BF measurement technique with high spatial-temporal resolution is needed for retinal imaging. Laser speckle imaging (LSI) is such a method. Currently, there are two analysis methods for LSI: spatial statistics LSI (SS-LSI) and temporal statistical LSI (TS-LSI). Comparing these two analysis methods, SS-LSI has higher signal to noise ratio (SNR) and TSLSI is less susceptible to artifacts from stationary speckle. We proposed a hybrid temporal and spatial analysis method (HTS-LSI) to measure the retinal blood flow. Gas challenge experiment was performed and images were analyzed by HTS-LSI. Results showed that HTS-LSI can not only remove the stationary speckle but also increase the SNR. Under 100% O2, retinal BF decreased by 20-30%. This was consistent with the results observed with laser Doppler technique. As retinal blood flow is a critical physiological parameter and its perturbation has been implicated in the early stages of many retinal diseases, HTS-LSI will be an efficient method in early detection of retina diseases.

Paper Details

Date Published: 17 February 2009
PDF: 7 pages
Proc. SPIE 7163, Ophthalmic Technologies XIX, 716304 (17 February 2009); doi: 10.1117/12.809906
Show Author Affiliations
Haiying Cheng, Emory Univ. (United States)
Yumei Yan, Emory Univ. (United States)
Timothy Q. Duong, Emory Univ. (United States)


Published in SPIE Proceedings Vol. 7163:
Ophthalmic Technologies XIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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