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Proceedings Paper

In vivo functional retinal optical coherence tomography fOCT
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Paper Abstract

Probing the retina with flicker light of defined frequencies allowed to offset the detection for intrinsic signals from proband motion artifacts as well as blood flow. In addition the fast imaging sequence capability of FDOCT is promising for the assessment of fast physiologic changes within retinal structures. For the present study two measurement protocols are evaluated: first, taking fast tomogram series across a flickered region, and then constructing via frequency analysis and bandpass filtering a functional OCT tomogram similar to fMRI. The second protocol consists of a fast local A-scan series at 17kHz rate with 1Hz flicker. 'Light-on' time is 250ms. 'Lights off' time is 750ms. 500ms before 'light-on' is used for calculating the baseline. Finally the average over 5 cycles is taken. A clear negative response is found at the outer photoreceptor segment for both 'light-on' and 'light-off' edge. The response appears to be stronger for the 'light off' edge. The shape of the responses is analysed and might eventually be used in linear regression models to enhance the sensitivity of our fOCT approach.

Paper Details

Date Published: 23 February 2009
PDF: 10 pages
Proc. SPIE 7163, Ophthalmic Technologies XIX, 71631J (23 February 2009); doi: 10.1117/12.809787
Show Author Affiliations
Rainer A. Leitgeb, Medical Univ. of Vienna (Austria)
Tilman Schmoll, Medical Univ. of Vienna (Austria)

Published in SPIE Proceedings Vol. 7163:
Ophthalmic Technologies XIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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