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Proceedings Paper

MRI-guided fluorescence tomography of the breast: a phantom study
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Paper Abstract

Tissue phantoms simulating the human breast were used to demonstrate the imaging capabilities of an MRI-coupled fluorescence molecular tomography (FMT) imaging system. Specifically, phantoms with low tumor-to-normal drug contrast and complex internal structure were imaged with the MR-coupled FMT system. Images of indocyanine green (ICG) fluorescence yield were recovered using a diffusion model-based approach capable of estimating the distribution of fluorescence activity in a tissue volume from tissue-boundary measurements of transmitted light. Tissue structural information, which can be determined from standard T1 and T2 MR images, was used to guide the recovery of fluorescence activity. The study revealed that this spatial guidance is critical for recovering images of fluorescence yield in tissue with low tumor-to-normal drug contrast.

Paper Details

Date Published: 20 February 2009
PDF: 7 pages
Proc. SPIE 7171, Multimodal Biomedical Imaging IV, 71710I (20 February 2009); doi: 10.1117/12.809735
Show Author Affiliations
Scott C. Davis, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)
Hamid Dehghani, The Univ. of Exeter (United Kingdom)
Dartmouth College (United States)
Keith D. Paulsen, Dartmouth College (United States)


Published in SPIE Proceedings Vol. 7171:
Multimodal Biomedical Imaging IV
Fred S. Azar; Xavier Intes, Editor(s)

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