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Proceedings Paper

Real-time dual wavelength polarimetry for glucose sensing
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Paper Abstract

Proper treatment of diabetes includes maintenance of near normal blood glucose levels, which can only be achieved with frequent blood glucose monitoring. Current blood finger-stick methods for glucose sensing are invasive, often resulting in low patient compliance and poor disease control. The development of a noninvasive glucose sensor has the potential to provide optimal management of diabetes. Our proposed noninvasive approach is based on an optical polarimetry system for probing the anterior chamber of the eye. The sensor would eventually be used to measure the aqueous humor glucose concentration as a means to determine the blood glucose concentration. In this report, we present the development of a near real-time (less than 1 second) dual wavelength closed-loop polarimetric system to minimize glucose prediction error in the presence of varying birefringence due to motion artifact. The new dual wavelength polarimetric system and in vitro glucose measurement results will be presented which demonstrate the sensitivity and accuracy of the system in the presence of varying birefringence.

Paper Details

Date Published: 20 February 2009
PDF: 5 pages
Proc. SPIE 7186, Optical Diagnostics and Sensing IX, 718604 (20 February 2009); doi: 10.1117/12.809681
Show Author Affiliations
Bilal H. Malik, Texas A&M Univ. (United States)
Gerard L. Coté, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 7186:
Optical Diagnostics and Sensing IX
Gerard L. Coté, Editor(s)

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