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Proceedings Paper

Two-photon-induced photoluminescence imaging of gold nanoshell's tumor biodistribution
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Paper Abstract

Given their tunable optical properties and high optical absorption and scattering cross sections, gold nanoshells (GNS) have been explored for a number of in vitro and in vivo imaging contrast and cancer therapy agents. While it has been shown that GNSs preferentially accumulate at the tumor site, little is known about the accumulation kinetics within the tumor. We demonstrate accumulation kinetics of GNSs in bulk tumors and histology slides using two-photon induced photoluminescence (TPIP) imaging. We found that GNSs had a heterogeneous distribution with higher accumulation at the tumor cortex. In addition, GNSs were observed in unique patterns surrounding the perivascular region. These results demonstrate that direct luminescence based imaging of metal nanoparticles provides high resolution and molecular specific multiplexed images.

Paper Details

Date Published: 18 February 2009
PDF: 9 pages
Proc. SPIE 7192, Plasmonics in Biology and Medicine VI, 71920T (18 February 2009); doi: 10.1117/12.809620
Show Author Affiliations
Jaesook Park, The Univ. of Texas at Austin (United States)
Arnold Estrada, The Univ. of Texas at Austin (United States)
Jon A. Schwartz, Nanospectra Biosciences, Inc. (United States)
Parmeswaran Diagaradjane, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Sunil Krishnan, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Chris Coleman, Nanospectra Biosciences, Inc. (United States)
J. Donald Payne, Nanospectra Biosciences, Inc. (United States)
Andrew K. Dunn, The Univ. of Texas at Austin (United States)
James W. Tunnell, The Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 7192:
Plasmonics in Biology and Medicine VI
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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