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Proceedings Paper

Possible role of laser phototherapy in laser immunotherapy
Author(s): Tomas Hode; Lars Hode
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Paper Abstract

Laser immunotherapy is a promising cancer treatment method that induces antitumor immunity and appears to be effective both locally and systemically. In this context, an important factor is the overall state of the immune system, both locally and systemically. The success of any immunotherapy treatment depends on the balance between the local immunosuppressive forces induced by the tumor and the immune response of the host organism. Factors that influence this balance include heat-shock proteins (for example HSP70), transforming growth factor β (TGF-β), tumor necrosis factor α (TNF-α), interleukins, and more. Laser phototherapy, which is based on non-thermal photobiological processes, has been shown to modulate the body's own immune response, both locally and systemically, with a strong influence on for example cytokine production and heat-shock protein synthesis. Laser phototherapy may therefore be an important component in the overall efficacy of laser immunotherapy, and may tip the balance between the immunosuppressive and immunostimulatory forces in favor of immunostimulation.

Paper Details

Date Published: 24 February 2009
PDF: 10 pages
Proc. SPIE 7178, Biophotonics and Immune Responses IV, 71780B (24 February 2009); doi: 10.1117/12.809529
Show Author Affiliations
Tomas Hode, Irradia USA (United States)
Lars Hode, Swedish Laser-Medical Society (Sweden)


Published in SPIE Proceedings Vol. 7178:
Biophotonics and Immune Responses IV
Wei R. Chen, Editor(s)

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