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Proceedings Paper

Oxygen saturation changes in the optic nerve head during acute intraocular pressure elevation in monkeys
Author(s): Bahram Khoobehi; Hiroyuki Kawano; Jinfeng Ning; Claude F. Burgoyne; David A. Rice; Fareeha Khan; Hilary W. Thompson; James M. Beach
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Paper Abstract

Background and Objective: To evaluate the effect of an acute elevated intraocular pressure (IOP) on oxygen saturation of structures of the optic nerve head. Study Design/Materials and Methods: In the cynomolgus monkey eye, IOP was set to 10 mm Hg, and then raised to 30, 45, and 55 mm Hg. The ONH and overlying vessels were imaged using a fundus camera attached to a hyperspectral imaging system (HSI) at 10 and 30 minutes after IOP elevation. Results: Raising IOP from 10 to 30 mm Hg did not significantly (P < 0.0001) change saturation in vessels or ONH tissue structures but at 55 mm Hg, all structures showed significant reduction. Conclusions: Quantitative assay of the blood oxygen saturation in structures on the surface and overlying the optic nerve head is possible using hyperspectral imaging techniques.

Paper Details

Date Published: 18 February 2009
PDF: 21 pages
Proc. SPIE 7163, Ophthalmic Technologies XIX, 716320 (18 February 2009); doi: 10.1117/12.809512
Show Author Affiliations
Bahram Khoobehi, Louisiana State Univ. Eye Ctr. (United States)
Hiroyuki Kawano, Louisiana State Univ. Eye Ctr. (United States)
Jinfeng Ning, Tulane Univ. (United States)
Claude F. Burgoyne, Devers Eye Institute (United States)
David A. Rice, Tulane Univ. (United States)
Fareeha Khan, Louisiana State Univ. Eye Ctr. (United States)
Hilary W. Thompson, Louisiana State Univ. Eye Ctr. (United States)
James M. Beach, Louisiana State Univ. Eye Ctr. (United States)
Stennis Space Ctr. (United States)

Published in SPIE Proceedings Vol. 7163:
Ophthalmic Technologies XIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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