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Proceedings Paper

Quantitative in vivo imaging of the lung using time-domain fluorescence measurements
Author(s): Guobin Ma; Muriel Jean-Jacques; Lysanne Melanson-Drapeau; Mario Khayat
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Paper Abstract

In this paper, nebulized or intravenous cetuximab (also known as Erbitux) labeled with NIR dyes is administered in the lungs of the mouse and imaged using a time-domain fluorescence imaging system (Optix(R)). Time resolved measurements provide lifetime of the fluorescent probes. In addition, through time-of-flight information contained in the data, one can also assess probe localization and concentration distribution quantitatively. Results shown include suppression of tissue autofluorescence by lifetime gating and recovery of targeted and non-targeted distributions of cetuximab labeled with the NIR fluorophores.

Paper Details

Date Published: 16 February 2009
PDF: 7 pages
Proc. SPIE 7191, Fluorescence In Vivo Imaging Based on Genetically Engineered Probes: From Living Cells to Whole Body Imaging IV, 71910C (16 February 2009); doi: 10.1117/12.809448
Show Author Affiliations
Guobin Ma, ART Advanced Research Technologies, Inc. (Canada)
Muriel Jean-Jacques, ART Advanced Research Technologies, Inc. (Canada)
Lysanne Melanson-Drapeau, ART Advanced Research Technologies, Inc. (Canada)
Mario Khayat, ART Advanced Research Technologies, Inc. (Canada)


Published in SPIE Proceedings Vol. 7191:
Fluorescence In Vivo Imaging Based on Genetically Engineered Probes: From Living Cells to Whole Body Imaging IV
Alexander P. Savitsky; Yingxiao Wang, Editor(s)

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