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Proceedings Paper

Terahertz spectroscopy of intrinsic biomarkers for non-melanoma skin cancer
Author(s): Cecil S. Joseph; Anna N. Yaroslavsky; Munir Al-Arashi; Thomas M. Goyette; Jason C. Dickinson; Andrew J. Gatesman; Brian W. Soper; Christopher M. Forgione; Thomas M. Horgan; Elizabeth J. Ehasz; Robert H. Giles; William E Nixon
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Paper Abstract

Continuous wave terahertz imaging has the potential to offer a safe, non-invasive medical imaging modality for detecting different types of human cancers. The aim of this study was to identify intrinsic biomarkers for non-melanoma skin cancer and their absorption frequencies. Knowledge of these frequencies is a prerequisite for the optimal development of a continuous wave terahertz imaging system for detecting different types of skin cancers. The absorption characteristics of skin constituents were studied between 20 and 100 cm-1 (0.6 THz - 3 THz). Terahertz radiation is highly absorbed by water. Thus, the high water content of human tissue necessitates a reflection based imaging modality. To demonstrate a reflection based, high resolution, terahertz imaging system, a prototype imaging system was constructed at 1.56 THz. The system resolution was determined to be 0.5 mm and the system signal to noise ratio was found to be 70 dB. Data from the terahertz spectroscopy experiments and reflection based terahertz images at 1.56 THz are presented.

Paper Details

Date Published: 9 February 2009
PDF: 10 pages
Proc. SPIE 7215, Terahertz Technology and Applications II, 72150I (9 February 2009); doi: 10.1117/12.809402
Show Author Affiliations
Cecil S. Joseph, Univ. of Massachusetts Lowell (United States)
Anna N. Yaroslavsky, Harvard Medical School, Massachusetts General Hospital (United States)
Munir Al-Arashi, Harvard Medical School, Massachusetts General Hospital (United States)
Thomas M. Goyette, Univ. of Massachusetts Lowell (United States)
Jason C. Dickinson, Univ. of Massachusetts Lowell (United States)
Andrew J. Gatesman, Univ. of Massachusetts Lowell (United States)
Brian W. Soper, Univ. of Massachusetts Lowell (United States)
Christopher M. Forgione, Univ. of Massachusetts Lowell (United States)
Thomas M. Horgan, Univ. of Massachusetts Lowell (United States)
Elizabeth J. Ehasz, Univ. of Massachusetts Lowell (United States)
Robert H. Giles, Univ. of Massachusetts Lowell (United States)
William E Nixon, National Ground Intelligence Ctr. (United States)


Published in SPIE Proceedings Vol. 7215:
Terahertz Technology and Applications II
Kurt J. Linden; Laurence P. Sadwick; Créidhe M. O'Sullivan, Editor(s)

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