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Proceedings Paper

Robust sensing films for pathogen detection and medical diagnostics
Author(s): Aaron S. Anderson; Andrew M. Dattelbaum; Harshini Mukundan; Dominique N. Price; W. Kevin Grace; Basil I. Swanson
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Paper Abstract

Our team has developed polyethylene glycol (PEG)-modified, self-assembled monolayers (SAMs) for biological detection on either planar or spherical substrates, which resist non-specific binding while facilitating specific ligand attachment. The preparation and characterization of these thin films, their validation against B. anthracis protective antigen (PA) in a sandwich assay format, and the application of these thin films for quantitative analysis of several medically interesting targets (breast cancer, tuberculosis, and influenza) will be shown.

Paper Details

Date Published: 19 February 2009
PDF: 10 pages
Proc. SPIE 7167, Frontiers in Pathogen Detection: From Nanosensors to Systems, 71670Q (19 February 2009); doi: 10.1117/12.809383
Show Author Affiliations
Aaron S. Anderson, Los Alamos National Lab. (United States)
Andrew M. Dattelbaum, Los Alamos National Lab. (United States)
Harshini Mukundan, Los Alamos National Lab. (United States)
Dominique N. Price, Los Alamos National Lab. (United States)
W. Kevin Grace, Los Alamos National Lab. (United States)
Basil I. Swanson, Los Alamos National Lab. (United States)


Published in SPIE Proceedings Vol. 7167:
Frontiers in Pathogen Detection: From Nanosensors to Systems
Philippe M. Fauchet, Editor(s)

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