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Proceedings Paper

In vivo noninvasive monitoring of microhemodynamics using optical-resolution photoacoustic microscopy
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Paper Abstract

Microvascular autoregulation is an intrinsic ability of vascular beds to compensate for the fluctuation in blood flow and tissue oxygen delivery. This function is crucial to maintaining the local metabolic activity. Here, using optical-resolution photoacoustic microscopy (OR-PAM), we clearly observed vasomotion and vasodilation in the intact mouse microcirculation in vivo in response to the changes in physiological state. Our results show that a significant lowfrequency vasomotion can be seen under hyperoxia but not hypoxia. Moreover, significant vasodilation is observed when the animal status is switched from hyperoxia to hypoxia. Our data show that arterioles have more pronounced vasodilation than venules.

Paper Details

Date Published: 24 February 2009
PDF: 7 pages
Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71770H (24 February 2009); doi: 10.1117/12.809297
Show Author Affiliations
Song Hu, Washington Univ. in St. Louis (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 7177:
Photons Plus Ultrasound: Imaging and Sensing 2009
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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