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Proceedings Paper

A novel fast imaging modality for free radicals in vivo: continuous wave (CW) EPR imaging with direct detection and rapid field scan in the presence of rotating gradients
Author(s): Sankaran Subramanian; Janusz W. Koscielniak; Nallathamby Devasahayam; Ghadi Salem; Randall H. Pursley; Thomas J. Pohida; Murali C. Krishna
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Paper Abstract

The work described in this presentation relates to a novel approach to Electron Paramagnetic Resonance imaging in vivo. The method employs a continuous wave approach to spectral detection without the conventional low frequency modulation and phase sensitive detection. A combination of direct detection and rapid field scan in the simultaneous presence of rotating gradients enables imaging with high temporal resolution. Since CW detection is not limited to free radical spin probes with narrow spectral lines, unlike the time-domain case, this novel approach uniquely accomplishes ultra fast functional imaging and is applicable to common redox-sensitive spin probes without line-width restriction.

Paper Details

Date Published: 23 February 2009
PDF: 14 pages
Proc. SPIE 7170, Design and Quality for Biomedical Technologies II, 717008 (23 February 2009); doi: 10.1117/12.809280
Show Author Affiliations
Sankaran Subramanian, National Institutes of Health (United States)
Janusz W. Koscielniak, National Institutes of Health (United States)
Nallathamby Devasahayam, National Institutes of Health (United States)
Ghadi Salem, SAIC-Frederick NCI Cancer Research and Development Center (United States)
Randall H. Pursley, SAIC-Frederick NCI Cancer Research and Development Center (United States)
Thomas J. Pohida, SAIC-Frederick NCI Cancer Research and Development Center (United States)
Murali C. Krishna, National Institutes of Health (United States)


Published in SPIE Proceedings Vol. 7170:
Design and Quality for Biomedical Technologies II
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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