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Proceedings Paper

Laparoscopic optical coherence tomographic imaging of human ovarian cancer
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Paper Abstract

Ovarian cancer is the fourth leading cause of cancer-related death among women. If diagnosed at early stages, 5-year survival rate is 94%, but drops to 68% for regional disease and 29% for distant metastasis; only 19% of cases are diagnosed at early, localized stages. Optical coherence tomography is a recently emerging non-destructive imaging technology, achieving high axial resolutions (10-20 µm) at imaging depths up to 2 mm. Previously, we studied OCT in normal and diseased human ovary ex vivo. Changes in collagen were suggested with several images that correlated with changes in collagen seen in malignancy. Areas of necrosis and blood vessels were also visualized using OCT, indicative of an underlying tissue abnormality. We recently developed a custom side-firing laparoscopic OCT (LOCT) probe fabricated for in vivo imaging. The LOCT probe, consisting of a 38 mm diameter handpiece terminated in a 280 mm long, 4.6 mm diameter tip for insertion into the laparoscopic trocar, is capable of obtaining up to 9.5 mm image lengths at 10 µm axial resolution. In this pilot study, we utilize the LOCT probe to image one or both ovaries of 17 patients undergoing laparotomy or transabdominal endoscopy and oophorectomy to determine if OCT is capable of differentiating normal and neoplastic ovary. We have laparoscopically imaged the ovaries of seventeen patients with no known complications. Initial data evaluation reveals qualitative distinguishability between the features of undiseased post-menopausal ovary and the cystic, non-homogenous appearance of neoplastic ovary such as serous cystadenoma and endometroid adenocarcinoma.

Paper Details

Date Published: 23 February 2009
PDF: 8 pages
Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71690S (23 February 2009); doi: 10.1117/12.809167
Show Author Affiliations
Lida P. Hariri, The Univ. of Arizona (United States)
Garret T. Bonnema, The Univ. of Arizona (United States)
Kathy Schmidt, The Univ. of Arizona (United States)
Vrushali Korde, The Univ. of Arizona (United States)
Amy M. Winkler, The Univ. of Arizona (United States)
Kenneth Hatch, The Univ. of Arizona (United States)
Molly Brewer, The Univ. of Arizona (United States)
Jennifer K. Barton, The Univ. of Arizona (United States)


Published in SPIE Proceedings Vol. 7169:
Advanced Biomedical and Clinical Diagnostic Systems VII
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest, Editor(s)

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