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Proceedings Paper

Effect of spontaneous diffusion in micro/nanoporous chemically crosslinked poly (N-vinyl imidazole) gel on the conformational changes of acetylcholine
Author(s): Evgenia Vaganova; Ines F. Pierola; Haim Ovadia; Sergey E. Lyshevski; Shlomo Yitzchaik
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Paper Abstract

Interdependent structural properties such as molecular conformation, flexibility and charge redistribution control the intermolecular interactions of acetylcholine (ACh) with adjacent molecules. This paper reports the results of an investigation of the effect of the diffusion of ACh through a nano/microporous poly (N-vinylimidazole) (PVI) gel on its structural properties, namely on changes in its conformation. To investigate the conformational changes of ACh during spontaneous diffusion through the gel, the fluorescence lifetime of the label molecule - fluorescein - was monitored. To clarify the results, analogous experiments were conducted with nicotinic acid and dopamine. In contrast to the nicotinic acid and dopamine, ACh can play the role of a regulator in molecular transport.

Paper Details

Date Published: 24 February 2009
PDF: 8 pages
Proc. SPIE 7185, Single Molecule Spectroscopy and Imaging II, 718516 (24 February 2009); doi: 10.1117/12.809083
Show Author Affiliations
Evgenia Vaganova, The Hebrew Univ. of Jerusalem (Israel)
Ines F. Pierola, Univ. Nacional de Educación a Distancia (Spain)
Haim Ovadia, Hadassah Univ. Hospital (Israel)
Sergey E. Lyshevski, Rochester Institute of Technology (United States)
Shlomo Yitzchaik, The Hebrew Univ. of Jerusalem (Israel)


Published in SPIE Proceedings Vol. 7185:
Single Molecule Spectroscopy and Imaging II
Jörg Enderlein; Zygmunt Karol Gryczynski; Rainer Erdmann, Editor(s)

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