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Proceedings Paper

System for fluorescence quantification of thin tissue layers guided by high frequency ultrasound
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Paper Abstract

A system is presented which has been developed for dermatological applications with the need to quantify levels of protoporphyrin IX in diagnosis or therapy. The design was to couple fluorescence sampling onto a high frequency ultrasound system and take multiple optical source-detector samples of the tissue of the fluorescence and transmission signals. The intensity values can then be used to estimate and image the PpIX levels present in tissue samples. The system design, calibration, and initial testing in tissue phantoms are demonstrated here. The component design has been modular and allows easy implementation as a kit which can be assembled from basic components. The control software is more elaborate and provides a seamless way to go from system start up through to fluorescence quantification of PpIX concentrations.

Paper Details

Date Published: 18 February 2009
PDF: 7 pages
Proc. SPIE 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, 71640N (18 February 2009); doi: 10.1117/12.809011
Show Author Affiliations
Josiah D. Gruber, Dartmouth College (United States)
Venkataramanan Krishnaswamy, Dartmouth College (United States)
Edward V. Maytin, Cleveland Clinic (United States)
Tayyaba Hasan, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Brian W. Pogue, Dartmouth College (United States)


Published in SPIE Proceedings Vol. 7164:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII
David H. Kessel, Editor(s)

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