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Proceedings Paper

Accuracy of the nonlinear fitting procedure for time-resolved measurements on diffusive phantoms at NIR wavelengths
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Paper Abstract

In this work we studied the accuracy of a non-linear fitting procedure, based on the Levenberg-Marquardt algorithm, for time-resolved measurements to retrieve the absorption and the reduced scattering coefficients of an absorbing diffusive medium. This procedure is suitable for retrieving optical properties in a wider range of situations (e.g. solid samples, reflectance geometry), with respect to the linear inversion procedures recently presented for both CW and time domain measurements. By means of both analytical and numerical (Monte Carlo) simulations, we quantified the influence of photon counts, temporal sampling, analytical model, background and instrument response function on the accuracy in the estimation of the optical properties. Also a new analytical model to describe light propagation in diffusive media based on the Radiative Transport Equation has been considered. The main source of error that affects the accuracy of the absorption and reduced scattering coefficients retrieved by the non-linear procedure appears to be the analytical model adopted in the inversion procedure.

Paper Details

Date Published: 12 February 2009
PDF: 10 pages
Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 717424 (12 February 2009); doi: 10.1117/12.808997
Show Author Affiliations
Lorenzo Spinelli, IIT, ULTRAS–INFM–CNR and IFN–CNR, Politecnico di Milano (Italy)
Fabrizio Martelli, Univ. degli Studi di Firenze (Italy)
Andrea Farina, IIT, ULTRAS–INFM–CNR and IFN–CNR, Politecnico di Milano (Italy)
Antonio Pifferi, IIT, ULTRAS–INFM–CNR and IFN–CNR, Politecnico di Milano (Italy)
Alessandro Torricelli, IIT, ULTRAS–INFM–CNR and IFN–CNR, Politecnico di Milano (Italy)
Rinaldo Cubeddu, IIT, ULTRAS–INFM–CNR and IFN–CNR, Politecnico di Milano (Italy)
Giovanni Zaccanti, Univ. degli Studi di Firenze (Italy)


Published in SPIE Proceedings Vol. 7174:
Optical Tomography and Spectroscopy of Tissue VIII
Bruce J. Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva M. Sevick-Muraca; Robert R. Alfano, Editor(s)

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