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Proceedings Paper

Brain tumor resection guided by fluorescence imaging
Author(s): Frederic Leblond; Kathryn M. Fontaine; Pablo Valdes; Songbai Ji; Brian W. Pogue; Alex Hartov; David W. Roberts; Keith D. Paulsen
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Paper Abstract

We present the methods that are being used in the scope of an on-going clinical trial designed to assess the usefulness of ALA-PpIX fluorescence imaging when used in conjunction with pre-operative MRI. The overall objective is to develop imaging-based neuronavigation approaches to aid in maximizing the completeness of brain tumor resection, thereby improving patient survival rate. In this paper we present the imaging methods that are used, emphasizing technical aspects relating to the fluorescence optical microscope, including initial validation approaches based on phantom and small-animal experiments. The surgical workflow is then described in detail based on a high-grade glioma resection we performed.

Paper Details

Date Published: 24 February 2009
PDF: 8 pages
Proc. SPIE 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, 71640M (24 February 2009); doi: 10.1117/12.808928

Published in SPIE Proceedings Vol. 7164:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII
David H. Kessel, Editor(s)

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