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Proceedings Paper

Experimental study on the influence of the metal film thickness on surface plasmon resonance biosensors
Author(s): Suihua Ma; Le Liu; Zhong Zhang; Yonghong He; Zhiyi Liu; Hui Ma; Jihua Guo; Zhanshan Wang
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Paper Abstract

In a SPR sensor, a glass slide is coated with a metal film, whose thicknesses, density and dielectric constant deadly affect the measurement sensitivity and precision in bio-detection. The optimum thickness of gold film used in SPR is between 40nm and 50nm without adhesive film, according to calculations based on multilayer reflection model cited in large numbers of literatures. But experimental study on the optimum film parameters are still lacking attribute to the limitation of film coating technology and high-precision thickness measurement technology. The optimum gold film thickness is not 45nm observed in our SPR bio-detection, and the property of adhesive film which is needed for enhancing the adhesion of metal film affects the SPR responsive bandwidth and minimum reflectivity. The experiment study on the sensor gold film and the property of adhesive film for SPR sensor are described in this paper using high precision SPR detection system, X-ray diffraction and magnetron sputtering technology. The optimum thickness for single gold film is 44nm and is 42nm for gold film with 2.4nm Cr adhesive layer. A new estimating factor is proposed to evaluate the quality and resolution of metallic film.

Paper Details

Date Published: 17 February 2009
PDF: 7 pages
Proc. SPIE 7192, Plasmonics in Biology and Medicine VI, 719211 (17 February 2009); doi: 10.1117/12.808923
Show Author Affiliations
Suihua Ma, Tsinghua Univ. (China)
Le Liu, Tsinghua Univ. (China)
Zhong Zhang, Tongji Univ. (China)
Yonghong He, Tsinghua Univ. (China)
Zhiyi Liu, Tsinghua Univ. (China)
Hui Ma, Tsinghua Univ. (China)
Jihua Guo, Tsinghua Univ. (China)
Zhanshan Wang, Tongji Univ. (China)


Published in SPIE Proceedings Vol. 7192:
Plasmonics in Biology and Medicine VI
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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