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Proceedings Paper

Detection of ultrasound-modulated photons and enhancement with ultrasound microbubbles
Author(s): David J. Hall; Mark J. Hsu; Sadik Esener; Robert F. Mattrey
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Paper Abstract

In vivo acousto-optic imaging promises to provide optical contrast at superior ultrasound spatial resolution. The main challenge is to detect ultrasound-modulated photons in the overwhelming presence of un-modulated photons. We have demonstrated in vitro detection of ultrasound-modulated photons with a variety of detection methods. Furthermore, we have detected ultrasound-modulated fluorescence offering potential for acousto-optic molecular imaging. Moreover, we have demonstrated the use of ultrasound microbubbles to significantly enhance the acousto-optic signal at the ultrasound frequency with the additional generation of higher order harmonic frequencies. Here the results from our various detection methods, ultrasound-modulated fluorescence, and enhancement with microbubbles are presented.

Paper Details

Date Published: 12 February 2009
PDF: 5 pages
Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71771L (12 February 2009); doi: 10.1117/12.808603
Show Author Affiliations
David J. Hall, Univ. of California, San Diego (United States)
Mark J. Hsu, Univ. of California, San Diego (United States)
Sadik Esener, Univ. of California, San Diego (United States)
Robert F. Mattrey, Univ. of California, San Diego (United States)

Published in SPIE Proceedings Vol. 7177:
Photons Plus Ultrasound: Imaging and Sensing 2009
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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