Share Email Print

Proceedings Paper

Monitoring tissue response during non-ablative irradiation of photorejuvenation with optical coherence tomography
Author(s): Yimei Huang; Wei Gong; Shusen Xie
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

With low risk of complications and no down-time, the non-ablative photorejuvenation is playing an increasing role in the therapy of the photodamaged skin. The light dose is one of the key factors that affect the performance of the photorejuvenation. Monitoring the tissue response during the procedure of laser irradiation would help to determine whether the light dose is appropriate. In this study, we developed a new approach to monitor the instant response of tissue irradiated by laser device by measuring the change of the total attenuation coefficient of the tissue with optical coherence tomography. The total attenuation coefficient was deduced from the raw data obtained by OCT with single scattering mode. Spatial and temporal equalizations were employed to improve the signal-to-noise ratio. We measured in vivo the total attenuation coefficients of the mouse back skin before and after laser irradiation. The total attenuation coefficients of the tissue reduced approximately 60% immediately after laser irradiation and then kept constant in a short time. The reduction of the attenuation coefficient depended on the light dose. These results demonstrated that the new approach could be a potential tool for monitoring in clinic in the future.

Paper Details

Date Published: 23 February 2009
PDF: 8 pages
Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 716110 (23 February 2009); doi: 10.1117/12.808587
Show Author Affiliations
Yimei Huang, Fujian Normal Univ. (China)
Wei Gong, Fujian Normal Univ. (China)
Shusen Xie, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 7161:
Photonic Therapeutics and Diagnostics V
Henry Hirschberg; Brian Jet-Fei Wong; Kenton W. Gregory; Reza S. Malek; Nikiforos Kollias; Bernard Choi; Guillermo J. Tearney; Justus F. R. Ilgner; Steen J. Madsen; Laura Marcu; Haishan Zeng, Editor(s)

© SPIE. Terms of Use
Back to Top