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Proceedings Paper

Selective inactivation of human immunodeficiency virus with an ultrashort pulsed laser
Author(s): K. T. Tsen; Shaw-Wei D. Tsen; Chien-Fu Hung; T.-C. Wu; Karen Kibler; Bert Jacobs; Juliann G. Kiang
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Paper Abstract

Recently, femtosecond laser technology has been shown to be effective in the inactivation of non-pathogenic viruses. In this paper, we demonstrate for the first time that infectious numbers of pathogenic viruses such as Human Immunodeficiency Virus (HIV) can be reduced by irradiation with subpicosecond near infrared laser pulses at a moderate laser power density. By comparing the threshold laser power density for the inactivation of HIV with those of human red blood cells and mouse dendritic cells, we conclude that it is plausible to use the ultrashort pulsed laser to selectively inactivate blood-borne pathogens such as HIV while leaving the sensitive materials like human red blood cells unharmed. This finding has important implications in the development of a new laser technology for disinfection of viral pathogens in blood products and in the clinic.

Paper Details

Date Published: 12 February 2009
PDF: 8 pages
Proc. SPIE 7175, Optical Interactions with Tissue and Cells XX, 717510 (12 February 2009); doi: 10.1117/12.808532
Show Author Affiliations
K. T. Tsen, Arizona State Univ. (United States)
Shaw-Wei D. Tsen, Johns Hopkins School of Medicine (United States)
Chien-Fu Hung, Johns Hopkins School of Medicine (United States)
T.-C. Wu, Johns Hopkins School of Medicine (United States)
Karen Kibler, Arizona State Univ. (United States)
Bert Jacobs, Arizona State Univ. (United States)
Juliann G. Kiang, Uniformed Services Univ. of The Health Sciences (United States)

Published in SPIE Proceedings Vol. 7175:
Optical Interactions with Tissue and Cells XX
Steven L. Jacques; E. Duco Jansen; William P. Roach, Editor(s)

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