Share Email Print
cover

Proceedings Paper

Photophysical and photochemical properties of α-(8-quinolinoxy) zinc phthalocyanine for photodynamic therapy
Author(s): Yuehui Lv; Songlin Yu; Huiyun Lin; Buhong Li; Jinping Xue; Shusen Xie
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

The photophysical and photochemical properties of a newly developed photosensitizer α-(8-quinolinoxy) zinc phthalocyanine (α-(8-QLO)PcZn) were investigated for application in photodynamic therapy (PDT). The maximal Q band for α-(8-QLO)PcZn in dimethylformamide around 675 nm with the molar extinction coefficient of about 1.89×105 mol-1cm-1. The fluorescence quantum and singlet oxygen (1O2) yields were determined to be 0.18±0.02 and 0.62±0.03, respectively. α-(8-QLO) PcZn has a diffuse cytoplasmic distribution in nasopharyngeal carcinoma C666-1 cells, and the efficient photodynamic cytotoxicity was observed. Our findings of this study suggest that α-(8-QLO)PcZn is a promising second-generation photosensitizer for PDT.

Paper Details

Date Published: 18 February 2009
PDF: 7 pages
Proc. SPIE 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, 71640W (18 February 2009); doi: 10.1117/12.808446
Show Author Affiliations
Yuehui Lv, Fujian Normal Univ. (China)
Songlin Yu, Fujian Normal Univ. (China)
Huiyun Lin, Fujian Normal Univ. (China)
Buhong Li, Fujian Normal Univ. (China)
Jinping Xue, Fuzhou Univ. (China)
Shusen Xie, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 7164:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII
David H. Kessel, Editor(s)

© SPIE. Terms of Use
Back to Top