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Proceedings Paper

Monte Carlo modeling of photon transport in buried bone tissue layer for quantitative Raman spectroscopy
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Paper Abstract

Light-scattering spectroscopy has the potential to provide information about bone composition via a fiber-optic probe placed on the skin. In order to design efficient probes, one must understand the effect of all tissue layers on photon transport. To quantitatively understand the effect of overlying tissue layers on the detected bone Raman signal, a layered Monte Carlo model was modified for Raman scattering. The model incorporated the absorption and scattering properties of three overlying tissue layers (dermis, subdermis, muscle), as well as the underlying bone tissue. The attenuation of the collected bone Raman signal, predominantly due to elastic light scattering in the overlying tissue layers, affected the carbonate/phosphate (C/P) ratio by increasing the standard deviation of the computational result. Furthermore, the mean C/P ratio varied when the relative thicknesses of the layers were varied and the elastic scattering coefficient at the Raman scattering wavelength of carbonate was modeled to be different from that at the Raman scattering wavelength of phosphate. These results represent the first portion of a computational study designed to predict optimal probe geometry and help to analyze detected signal for Raman scattering experiments involving bone.

Paper Details

Date Published: 18 February 2009
PDF: 10 pages
Proc. SPIE 7166, Optics in Bone Biology and Diagnostics, 716604 (18 February 2009); doi: 10.1117/12.808417
Show Author Affiliations
Robert H. Wilson, Univ. of Michigan (United States)
Kathryn A. Dooley, Univ. of Michigan (United States)
Michael D. Morris, Univ. of Michigan (United States)
Mary-Ann Mycek, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 7166:
Optics in Bone Biology and Diagnostics
Andreas Mandelis, Editor(s)

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